International Review of Ophthalmology

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Recent progress in investigation of potential therapeutic action of PPAR-γ in the diabetic retinopathy

JIANG Ling.   

  1. Department of Ophthalmology, the People's Hospital of Pengzhou City, Sichuan Province, Pengzhou 611930, China
  • Received:2016-08-11 Online:2016-12-22 Published:2016-12-21
  • Contact: JIANG Ling， Email: 36723394@qq.com

Abstract:

Diabetic retinopathy is an important cause of blindness. Inflammatory processes have an important role in the diabetic retinopathy. Peroxisome
proliferator-activated receptor-γ (PPAR-γ) not only increases insulin sensitivity, but also inhibits inflammatory processes and cell proliferation. Therefore,
activation of PPAR-γ may be effective for treating diabetic retinopathy. Those functions of PPAR-γ and ideas for medicine therapeutic to diabetic retinopathy are
summarized in this review. (Int Rev Ophthalmol, 2016, 40: 391-394)